Simultaneous Determination of Amlodipine and Valsartan
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چکیده
منابع مشابه
Simultaneous Determination of Amlodipine and Valsartan
A spectrophotometric method was developed for simultaneous determination of amlodipine (Aml) and valsartan (Val) without previous separation. In this method amlodipine in methanolic solution was determined using zero order UV spectrophotometry by measuring its absorbency at 360.5 nm without any interference from valsartan.Valsartan spectrum in zero order is totally overlapped with that of amlod...
متن کاملValidated Rp-hplc Method for Simultaneous Determination of Amlodipine, Hydrochlorothiazide and Valsartan in Pharmaceutical Formulation
An accurate, precise and reproducible reverse-phase stability-indicating HPLC method has been developed and validated for the simultaneous estimation of Amlodipine, Hydrochlorothiazide and Valsartan in combined dosage form. Separation was achieved using Phenomenex ODS 5μ, C18 column (250×4.6mm) and ACN : Methanol : 1% Triethylamine Buffer (39:26:35) as mobile phase which shows sharp and resolve...
متن کاملSimultaneous determination of amlodipine, valsartan and hydrochlorothiazide by LC–ESI-MS/MS and its application to pharmacokinetics in rats
Polypill is a fixed-dose combination that contains three or more active ingredients used as a single daily pill to achieve a large effect in preventing cardiovascular disease with minimal adverse effects. A novel and accurate liquid chromatography tandem mass spectrometry method using electrospray ionization mode has been developed and validated for the simultaneous determination of amlodipine ...
متن کاملSimultaneous Determination of Dofetilide and Amlodipine in Plasma by HPLC
Dofetilide is a Class III antiarrhythmic drug useful in the management of atrial fibrillation but also known to prolong the QT interval on the ECG and to induce malignant ventricular tachyarrhythmias such as torsades de pointes (TDP). Drugs with calcium channel-blocking properties contribute to decrease the incidence of TDP. Amlodipine is a dihydropyridine calcium channel antagonist. Considerin...
متن کاملReal-world effectiveness of amlodipine/valsartan and amlodipine/valsartan/hydrochlorothiazide in high-risk patients and other subgroups
BACKGROUND The clinical EXCITE (EXperienCe of amlodIpine and valsarTan in hypErtension) study reported clinically relevant blood pressure (BP) reductions across all doses of amlodipine/valsartan (Aml/Val) and Aml/Val/hydrochlorothiazide (HCT) single-pill combinations. The study prospectively observed a multiethnic population of hypertensive patients for 26 weeks who were treated according to ro...
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ژورنال
عنوان ژورنال: Analytical Chemistry Insights
سال: 2011
ISSN: 1177-3901,1177-3901
DOI: 10.4137/aci.s7282